Cytokine Signaling in the Microenvironment May Aid in Tumor Development and Progression

Authors

Dr. Kim O'Neill, Brigham Young University

Keywords

cytokine signaling, microenvironment, tumor development, tumor progression

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Studies have indicated that in breast tumors a high number of tumor associated macrophages (TAM’s) is indicative of a poor prognosis. TAM’s in the breast tumor microenvironment generally have a compromised immune response and focus their energy toward tissue repair which leads to angiogenesis, tumor growth, and metastasis. These macrophages have been termed M2 macrophages. Conversely, studies also indicate that in the microenvironment of some colon cancers, M1 phenotypic macrophages are present and that a high number of TAM’s is associated with a good prognosis.

Recommended Citation

O'Neill, Dr. Kim (2013) "Cytokine Signaling in the Microenvironment May Aid in Tumor Development and Progression," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1819.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1819