Tumor Drug Concentration Due to Ultrasonic Drug Delivery

Authors

Bryant Staples, Brigham Young University
Dr. William Pitt, Brigham Young University

Keywords

tumor drug concentration, ultrasonic drug delivery, hydrophobic drugs

College

Ira A. Fulton College of Engineering and Technology

Department

Chemical Engineering

Abstract

The tri-block copolymer, Pluronic P105, has been found to be an ideal ultrasonically activated drug delivery vehicle because it forms micelles with hydrophobic polypropylene oxide cores that sequester hydrophobic drugs (Fig. 1). These micelles release their contents upon the application of low frequency ultrasound [1] such that drugs can be released specifically at the ultrasonicated region (Fig. 2). Such ultrasonically controlled release has been effective against cancer cells in vitro [2] and in vivo [3].

Recommended Citation

Staples, Bryant and Pitt, Dr. William (2013) "Tumor Drug Concentration Due to Ultrasonic Drug Delivery," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1760.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1760