Mutagenesis of the Voltage-Gated Na+ Channel: S4 Charge Interaction with u-Conotoxin

Authors

David Allan Edwards, Brigham Young University
R. Paul Evans, Brigham Young University

Keywords

mutagenesis, voltage-gated, Na+ channel, u-conotoxin

College

Life Sciences

Department

Plant and Wildlife Sciences

Abstract

Within the membrane of excitable cells like those of nerve and muscle tissue, lie proteins called ion channels, which control the passage of ions in and out of the cell. The flow of ions stimulates the action of the cell, which ultimately leads to contraction of muscle tissue in the case of muscle cells, and sensation in the case of nerve cells. Seizures and pain sensation are extreme results of the action of these cells. To control pain, for example, we may use anesthetics that directly interact with ion channels and prevent the flow of ions across the cell membrane. And, in order to design effective drugs, knowledge of the ion channel’s geometry, action, and interaction with other molecules is crucial.

Recommended Citation

Edwards, David Allan and Evans, R. Paul (2013) "Mutagenesis of the Voltage-Gated Na+ Channel: S4 Charge Interaction with u-Conotoxin," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1597.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1597