Comparisons of Amantadine Analogues against the Dominant Influenza A Virus M2 Proton Channel Mutant via Circular Dichroism Spectroscopy and Tryptophan Fluorescence Anisotropy

Authors

Trevor Anderson, Brigham Young University
David Busath, Brigham Young University

Keywords

influenza A virus, M2 proton channel, circular dichroism spectroscopy, tryptophan fluorescence anisotropy

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

The influenza A virus is a severe ongoing threat to public health, accounting for over 250,000 fatalities worldwide each year. In order to actuate the virus, it is necessary for the M2 proton channel to be activated upon fusion with an endosome.

Recommended Citation

Anderson, Trevor and Busath, David (2013) "Comparisons of Amantadine Analogues against the Dominant Influenza A Virus M2 Proton Channel Mutant via Circular Dichroism Spectroscopy and Tryptophan Fluorescence Anisotropy," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1526.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1526