A Novel Role for AMP-activated Protein Kinase as a Selective Inhibitor of de novo Ceramide Biosynthesis

Authors

Kate Erickson, Brigham Young University
Dr. Benjamin Bikman, Brigham Young University

Keywords

AMP-activated protein kinase, AMPK, de novo ceramide biosynthesis

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

The purpose of this project was to determine the cellular mechanisms that mediate AMPK-induced reductions in lipotoxicity. We predicted that AMPK activation inhibits lipotoxic ceramide biosynthesis via targeted reduction in transcription of a critical, rate-limiting enzyme involved in de novo ceramide synthesis.

Recommended Citation

Erickson, Kate and Bikman, Dr. Benjamin (2013) "A Novel Role for AMP-activated Protein Kinase as a Selective Inhibitor of de novo Ceramide Biosynthesis," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1523.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1523