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Journal of Undergraduate Research

Keywords

Rho Kinase Pathway, epithelial-mesenchymal transition, EMT

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

The Rho Kinase Pathway is a cellular pathway that is thought to be involved in cancer metastasis, as previous research has indicated1. As indicated by the name, the Rho group of proteins are central to this pathway. Over the past year, we set out to analyze this pathway and to further our understanding of its role in epithelial-mesenchymal transition (EMT), a biological process common in many metastatic cancers. Through experimental analysis, we were able to look at this pathway in ways that no one else has been able to. While our results were very intriguing, obtaining the data was an arduous process. Multiple experiments failed along the way, and multiple set-backs forced us to restart on many of the experiments and data analysis we had already performed. These set-backs were frustrating at times, but helped us achieve a more accurate portrayal of the data we wanted to publish. In the coming months, the data we have gathered will be presented at the Tumor Invasion and Metastasis Conference held by the American Association for Cancer Research in San Diego this January. We also hope to publish our data in a scientific journal once all the final details have been made, and will be submitting our research for publication during the 2013 winter semester.

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