Destabilization of the Medial Meniscus: A Non-Genetic Approach to Inducing Osteoarthritis in Mice

Authors

Christopher Stockdale, Brigham Young University
Joshua Lloyd, Brigham Young University
Dr. Robert E. Seegiller, Brigham Young University

Keywords

medial meniscus, osteoarthritis, mice, destabilization

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Osteoarthritis (OA) is a common disease that causes discomfort and pain due to the degradation of the articular cartilage found on the surface of bones within the body’s joints. A properly functioning joint has a strong network of articular cartilage that can handle the constant strain caused by the use and movement of the joints. Individuals who suffer with OA have a compromised cartilage network that can result in softening of the cartilage, rough joint surfaces, fissures in the cartilage, and eventually direct bone on bone contact within the joint.

Recommended Citation

Stockdale, Christopher; Lloyd, Joshua; and Seegiller, Dr. Robert E. (2013) "Destabilization of the Medial Meniscus: A Non-Genetic Approach to Inducing Osteoarthritis in Mice," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1504.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1504