Ror2/Wnt5a Mediated Directional Limb Outgrowth

Authors

Aaron Smith, Brigham Young University
Dr. Jeff Barrow, Brigham Young University

Keywords

Ror2, Wnt5a, limb outgrowth, AER, apical ectodermal ridge

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

The apical ectodermal ridge (AER) is a small strip of epithelial tissue that is found at the distal tip of the embryonic vertebrate limb and runs from anterior to posterior. It is known that the AER is necessary to maintain the life of mesenchymal cells (interior non-surface cells) of the limb and is also necessary to maintain other important signaling centers in the limb (citations). The AER is also believed to be responsible for patterning the limb along the proximal to distal axis. However, it is unknown what precise role the AER plays in this and researchers have been attempting to uncover this role over the past forty to fifty years (Dudley et al., 2002).

Recommended Citation

Smith, Aaron and Barrow, Dr. Jeff (2013) "Ror2/Wnt5a Mediated Directional Limb Outgrowth," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1500.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1500