Inhibition of Notch Signaling Increases Neurogenesis in the Ophthalmic Trigeminal Placode without Expanding the Domain of Neurogenin2 Expression.

Authors

Brian Wright, Brigham Young University
Dr. Michael Stark, Brigham Young University

Keywords

notch signaling, neurogenin2, ophthalmic trigeminal placode

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

The ever-increasing knowledge regarding cellular regulation and programming requires important insights into the biochemical pathways that determine a cell’s fate. For example, the ability to take a stem cell and grow it into a neuron will directly depend on our knowledge of the steps used in the embryo for normal neurogenesis, or the formation of neurons. The ophthalmic placode (a region of thickening cells) of the trigeminal nerve provides a valuable model for studying sensory neurogenesis, since it gives rise exclusively to sensory neurons. This nerve provides tactile sensation to the upper region of the face.

Recommended Citation

Wright, Brian and Stark, Dr. Michael (2013) "Inhibition of Notch Signaling Increases Neurogenesis in the Ophthalmic Trigeminal Placode without Expanding the Domain of Neurogenin2 Expression.," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1498.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1498