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Journal of Undergraduate Research

Keywords

RHD, round heart disease, turkey, cadiomyopathy

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Round heart disease (RHD) is a spontaneous occurring cardiomyopathy in turkeys. The domestic turkey Meleagris gallopavo is affected by low body weight and premature death due to congestive heart failure from RHD (1). RHD results in decreased profitability for the animal agriculturists and higher prices for turkey products. DNA markers have been identified for both normal turkeys and for turkeys affected by RHD. These genetic markers have been amplified using Random Amplified Polymorphic DNA (RAPD) analysis (2). 16 DNA marker sequences amplified by RAPD have now been determined (3). Basic Local Alignment Search Tool (BLAST) is a computer program designed to search homology of the query DNA in the available DNA and protein sequence databases (4). Here we describe how BLAST was utilized to find homologous DNA and putative protein sequences of the RHD nucleotide marker sequences. Furthermore, we propose possible mechanisms of RHD.

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