Journal of Undergraduate Research
Keywords
Col11a1, mutation, mice, BAC, Bacterial Artificial Chromosome
College
Life Sciences
Department
Physiology and Developmental Biology
Abstract
Collagen fibrils play an important role in proper skeletal development. Defective collagen can cause human skeletal disorders such as osteoarthritis that affects an estimated 20.7 million Americans. A particular mouse line, housed here at BYU, contains a mutation in the Col11a1 gene. This mutation results in defective type XI collagen, which is an important component of articular cartilage, and eventually leads to osteoarthritis (1).
Recommended Citation
Murphy, Dana L. and Bridgewater, Dr. Laura C.
(2013)
"Construction of a COL11A1 Transgene and the Study of the COL11A1 Mutation in Mice,"
Journal of Undergraduate Research: Vol. 2013:
Iss.
1, Article 1490.
Available at:
https://scholarsarchive.byu.edu/jur/vol2013/iss1/1490