Histological and Ultrastructural Evidence of Osteoarthritis in Mice Carrying a Semi-Dominant Mutation of Col2A1

Authors

Victoria Ryder, Brigham Young University
Dr. Robert Seegmiller, Brigham Young University

Keywords

osteoarthritis, mice, semi-dominant mutation, Col2A1, Dmm, disproportionate micromelia mice

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Mice heterozygous for the semi-dominant mutation disproportionate micromelia (Dmm) express mild chondrodysplasia by three weeks postnatally. This phenotype is attributed to a deletion of three contiguous nucleotides within the Col2A1 gene on mouse chromosome 15. The phenotype of Dmm/+ mice resembles that of human Stickler syndrome, which can be caused by mutations in the human COL2A1 gene.

Recommended Citation

Ryder, Victoria and Seegmiller, Dr. Robert (2013) "Histological and Ultrastructural Evidence of Osteoarthritis in Mice Carrying a Semi-Dominant Mutation of Col2A1," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1483.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1483