EFFECTS OF INTERLEUKIN-6, INTERLEUKIN-1, AND TUMOR NECROSIS FACTOR ON ADRENAL STEROID SECRETIONS

Authors

Brenda Mickelson Crawford, Brigham Young University
Dr. Allan M. Judd, Brigham Young University

Keywords

interleukin-6, interleukin-1, tumor necrosis, adrenal steroid secretions

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Interleukin-6 (IL-6), tumor necrosis factor (TNF), and interleukin- I (IL- 1) are cytokines released in response to infection in the body. One signal of infection is lipopolysaccharide (LPS), a component of the outer coat of grain negative bacterial cells. When bacteria die, LPS circulates in the blood and stimulates the immune system to release IL- 1, IL-6, and TNF. Septic shock is a syndrome in which LPS stimulates the release of large amounts of cytokines, causing adverse effects such as severe hypotension (low blood pressure), rashes, fever, edema, and finally multiple organ failure, including the heart.

Recommended Citation

Crawford, Brenda Mickelson and Judd, Dr. Allan M. (2013) "EFFECTS OF INTERLEUKIN-6, INTERLEUKIN-1, AND TUMOR NECROSIS FACTOR ON ADRENAL STEROID SECRETIONS," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1465.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1465