Journal of Undergraduate Research
Keywords
TRPV1, synaptic plasticity, hippocampus, neuronal synapses
College
Life Sciences
Department
Physiology and Developmental Biology
Abstract
Learning and memory are phenomena that are made possible via physical changes at neuronal synapses in the brain, a phenomenon known as synaptic plasticity. Because synaptic plasticity affects physical changes in the brain in response to external stimuli, it is suspected of playing an essential role in strengthening or weakening the neural pathways regulating short-term learning and memory within the hippocampus. Dysfunctions in synaptic plasticity contribute to such diseases and disorders as Alzheimer’s Disease, Parkinson’s Disease, and retrograde amnesia.1 By further clarifying the mechanism of synaptic plasticity, in which TRPV1 is suspected of participating, I have tried to fill a research gap that may bring science and medicine a step closer to producing treatments for such debilitating illnesses. Certain receptors that mediate synaptic plasticity have been extensively studied, specifically the NMDA and other glutamate receptors, while the TRPV1 receptor, which is likely to modulate plasticity, has received far less attention. My specific area of research has explored the effect of TRPV1 activation and blockade in modulating LTP and among the pyramidal cells of the CA1 region of the hippocampus.
Recommended Citation
Bennion, Douglas and Edwards, Dr. Jeff
(2013)
"TRPV1 Modulation of Synaptic Plasticity in the Hippocampus,"
Journal of Undergraduate Research: Vol. 2013:
Iss.
1, Article 1463.
Available at:
https://scholarsarchive.byu.edu/jur/vol2013/iss1/1463