Modifying the Apical Ectodermal Ridge in Embryological Development of Vertebrates

Authors

Lauren Clough, Brigham Young University
Dr. Jeffery R. Barrow, Brigham Young University

Keywords

apical ectodermal ridge, AER, embryological development, vertebrates

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Vertebrate embryonic limb development is a complex process that involves many genes and processes. Patterning takes place along three axes, including the proximal-distal axis of the limb. The Apical Ectodermal Ridge (AER) helps to guide development along the proximal-distal axis, but the genetic and cellular mechanisms whereby it performs its roles are not well understood. This study attempted to discover whether the AER is able to recruit limb cells through oriented cell division through experiments with surgical manipulation of the AER in chicks and genetic manipulation in mice. By using cellular markers to determine apoptotic and mitotic indices, we have collected data that will help form a foundation for future studies in this project and will ultimately help reveal the role of the AER in the development of the vertebrate limb.

Recommended Citation

Clough, Lauren and Barrow, Dr. Jeffery R. (2013) "Modifying the Apical Ectodermal Ridge in Embryological Development of Vertebrates," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1460.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1460