•  
  •  
 

Journal of Undergraduate Research

Keywords

TLR-4 blockers, OA, RAGE, Receptor for Advanced Glycation End, mice

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

As the population in the US continues to age, osteoarthritis (OA) is becoming a larger issue, currently effecting over 27 million people1. Presently, pharmaceutical options aim to lessen the effects of the disease, while no preventative treatment is currently available. Much of the current arthritis research is targeted at the effects of inflammation on the progression of OA. Our lab has shown in previous research that mice lacking the Receptor for Advanced Glycation End Products (RAGE) are protected from OA2. Other labs have shown the possibility of Toll-like receptor 4 (TLR-4) involvement in the progression of the disease as well3. The goal of this project was to determine the effects of blocking TLR-4 and the RAGE pathways in the progression of (OA). The data presented in this report are preliminary, due to the augmentation of the proposed experimental design to include additional controls. This expansion has set back our initial timetable.

Download

Included in

Physiology Commons

Share

COinS