Histological Validation Of Iron As An Imaging Biomarker for Amyloid Beta And Tau Depositions in Alzheimer’s Disease

Authors

Ashley Salin, Brigham Young University
Dr. Jonathan Wisco, Brigham Young University

Keywords

histological validation, iron, amyloid beta, tau depositions, Alzheimer's Disease

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

At present, no one can diagnose a patient with Alzheimer’s disease until postmortem examination. It was our goal to change that theory and make it possible to diagnose varying degrees of Alzheimer’s through Magnetic Resonance Imaging. Analysis of the spatial overlap of non-heme iron, phosphorylated tau protein, and Amyloid Beta depositions in consecutive tissue slices of the hippocampus of post-mortem subjects ultimately facilitated characterization and detection of diseases, such as Alzheimer’s through MRI’s.

Recommended Citation

Salin, Ashley and Wisco, Dr. Jonathan (2013) "Histological Validation Of Iron As An Imaging Biomarker for Amyloid Beta And Tau Depositions in Alzheimer’s Disease," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1445.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1445