Retinal Detachment in Mice with Disproportionate Micromelia

Authors

Jared R. Jackson, Brigham Young University
Dr. Robert Seegmiller, Brigham Young University

Keywords

retinal detachment, mice, disproportionate micromelia mice, Dmm

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Stickler syndrome, caused by a mutation of the Collagen 2A1 gene, is the most common cause of inherited retinal detachment in children. A mutation of the same gene in mice causes Disproportionate Micromelia (Dmm). “In cases where mouse mutations occur in genes that are also responsible for human disorders, the mouse strains provide essential model systems for studies of pathogenetic mechanisms.” The purpose of this study is to find and document evidence of retinal detachment that is hypothesized in heterozygous (Dmm/+) mutant mice.

Recommended Citation

Jackson, Jared R. and Seegmiller, Dr. Robert (2013) "Retinal Detachment in Mice with Disproportionate Micromelia," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1440.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1440