THE EFFECT OF ESTRONE ON THE INTERACTION BETWEEN PHOSPHOLIPASE A AND THE PHOSPHOLIPID BILAYER

Authors

Eric M. Troxell, Brigham Young University
Marci L. Troxell, Brigham Young University
Dr. Marci L. Troxell, Brigham Young University
John D. Bell, Brigham Young University

Keywords

estrone, interaction, phospholipase, phospholipid bilayer

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Phospholipase A is a protein that interacts reversibly with the phospholipid bilayer of cell membranes. This interaction is affected by physical alterations in the bilayer, which can be caused by a variety of sources, including temperature and certain drugs. Cholesterol is one of the sources known to change the physical properties of the bilayer. It was hypothesized that estrone (Cl8H2202), which is similar in structure to cholesterol, would also affect the bilayer. Studying the effects of various drugs on the bilayer and phospholipase A2 can lead to greater understanding of the lipid/protein interactions occurring in cells.

Recommended Citation

Troxell, Eric M.; Troxell, Marci L.; Troxell, Dr. Marci L.; and Bell, John D. (2013) "THE EFFECT OF ESTRONE ON THE INTERACTION BETWEEN PHOSPHOLIPASE A AND THE PHOSPHOLIPID BILAYER," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1437.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1437