Molecular Modeling Dynamics Simulations of BoTox and

Authors

Richard Swenson, Brigham Young University
David Busath, Brigham Young University

Keywords

molecular modeling, BoTox, Notulinum Neurotoxin, Phospholipase A-2, sPLA2

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

In general, research of the function of proteins involved in harmful diseases helps researchers who are investigating these diseases better understand part of their puzzle to be able to find solutions to these problems and often opens doors for new treatments of other disorders. For example, to reduce wrinkles, doctors inject patients with Botulinum Neurotoxin(BoTox). I would like to add to the world’s understanding of BoTox so that new procedures can be developed and the harmful effects of botulism can be reduced. My research of Phospholipase A-2 (sPLA2) will likewise add to knowledge of the function of this and other similar proteins. sPLA2 is thought to play a role in atherosclerosis, gall stones, inflammatory diseases, and other disorders.

Recommended Citation

Swenson, Richard and Busath, David (2013) "Molecular Modeling Dynamics Simulations of BoTox and," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1428.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1428