PHYLOGENETIC ANALYSES OF THE GEOGRAPHIC ORIGIN OF STLV-I AND HTLV-I WITH EXTENSIVE SEQUENCE SAMPLING: EVIDENCE FOR AN AFRICAN ORIGIN WITH SUBSEQUENT SEPARATE VIRAL EVOLUTION IN ASIA AND AFRICA

Authors

Chris R. Kelsey, Brigham Young University
Dr. Keith A. Crandall, Brigham Young University

Keywords

HTLV-I and STLV-I lineages, leukemia, lymphoma, phylogenetic relationships

College

Life Sciences

Department

Psychology

Abstract

Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus believed to be the etiologic agent of adult T-cell leukemia/lymphoma (ATL) and HTLV-I -associated myelopathy/ tropical spastic paraparesis (HAM/TSP). HTLV-I is a member of a related group of retroviruses, known collectively as primate T-cell lymphotropic viruses (PTLV) which also include human T-cell lymphotropic virus type II (HTLV-II) and the simian T-cell lymphotropic virus type I (STLV-I). In an attempt to better understand phylogenetic relationships among geographically diverse strains of PTLV-I, and in the process gain more insight into the geographic origin of STLV-I and HTLV-I, a comprehensive study involving multiple regions of the viral genome and multiple phylogenetic methods was performed.

Recommended Citation

Kelsey, Chris R. and Crandall, Dr. Keith A. (2013) "PHYLOGENETIC ANALYSES OF THE GEOGRAPHIC ORIGIN OF STLV-I AND HTLV-I WITH EXTENSIVE SEQUENCE SAMPLING: EVIDENCE FOR AN AFRICAN ORIGIN WITH SUBSEQUENT SEPARATE VIRAL EVOLUTION IN ASIA AND AFRICA," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1424.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1424