The Role of AP-1 and Related Inhibitors in Cortisol Secretion and Inflammation

Authors

D. Craig Seager, Brigham Young University
Dr. Allan Judd, Brigham Young University

Keywords

AP-1, cortisol secretion, inflammation, activator protein-1

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Interleukin-6 (IL-6) increases the secretion of cortisol from bovine adrenal zona fasciculata (ZF) and human adrenal tumor H295R cells. However, the biochemical mechanisms involved in IL- 6-stimulated cortisol secretion are not well understood. In previous studies, it has been determined that IL-6 increases the phosphorylation of Janus kinases (JAK) and signal transducer and activators of transcription (STATs). In many tissues, the JAK-STAT pathway and the activator protein-1 (AP-1) pathways interact. AP-1 is composed of homodimers and heterodimers of the proteins c-Fos, c-Jun, JunB, and JunD. Therefore, in this study we determined the effects of IL-6 on the cellular content of the mRNAs for c-Fos, c-Jun- JunB, and JunD.

Recommended Citation

Seager, D. Craig and Judd, Dr. Allan (2013) "The Role of AP-1 and Related Inhibitors in Cortisol Secretion and Inflammation," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1391.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1391