Effect of High Fat Diet With AICAR Treatment on Mitochondrial Biogenesis of Male Rats

Authors

David Mills, Brigham Young University
Chad Hancock, Brigham Young University

Keywords

high fact diet, AICAR treatment, mitochondrial biogenesis, male rats

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

The original goal for my project was to study how a high-fat diet affects insulin resistance in slow twitch and fast twitch muscle fibers in rats. We hypothesized that administering a drug named acipamox, which lowers cellular free fatty acid levels, would restore insulin sensitivity in both slow twitch and fast twitch muscle fibers. Previously published research showed that acipamox restored insulin sensitivity in slow twitch fibers (1) but this study did not address what happened in the fast twitch muscle fibers.

Recommended Citation

Mills, David and Hancock, Chad (2013) "Effect of High Fat Diet With AICAR Treatment on Mitochondrial Biogenesis of Male Rats," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1374.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1374