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Journal of Undergraduate Research

Keywords

selenium, androgen receptor, nuclear factor kappa-b, NF-κB, cancer

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

Selenium has been established as a promising chemopreventive element for prostate cancer. Several different mechanisms have been studied to delineate selenium’s anti-cancer effect, but the exact target and mechanism has yet to be clearly defined. Previous studies have established an inhibitory relationship between the nuclear factor kappa B (NF-κB) and selenium, as well as the Androgen Receptor (AR) and selenium in human LNCap cells. Both NF-κB and AR are constituently active during prostate cancer development, and their deactivation by selenium might be one of the mechanisms by which selenium acts as a chemopreventative agent. The purpose of our research is to study the interaction between AR and NF-κB in the selenium pathway. More specifically, in this study we evaluated the effect of selenium in the form of methyselenilic acid (MSA) on the expression of AR and the subunits of NF-κB, p50 and p65.

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