Determining the Role of Kaposi’s Sarcoma-associated Herpesvirus LANA Protein in the Development of Persistent Infection

Authors

Jamie Gardiner, Brigham Young University
Dr. Brad Berges, Brigham Young University

Keywords

Kaposi's sarcoma, LANA protein, infection, herpesvirus

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is a human cancer virus that causes Kaposis’ sarcoma, the most common cancer found in AIDS patients. Our lab is working to develop humanized mice as a novel animal model to study KSHV infection and related diseases, since there has previously been no animal model established. The purpose of my project was to determine the role of the viral protein LANA (latencyassociated nuclear antigen) in establishing a latent KSHV infection in humanized mice. My project included two major aims:

Recommended Citation

Gardiner, Jamie and Berges, Dr. Brad (2023) "Determining the Role of Kaposi’s Sarcoma-associated Herpesvirus LANA Protein in the Development of Persistent Infection," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1351.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1351