Identifying Proteins that Interact with Human PAS kinase

Authors

Tacie Hall, Brigham Young University
Dr. Julianne Grose, Brigham Young University

Keywords

human PAS kinase, high-fat diets, mice, metabolic pathways

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

When PAS kinase is knocked out in mice placed on high-fat diets, these mice show such symptoms as decreased weight gain, hypermetabolic phenotype, decreased liver triglyceride accumulation, and retained insulin sensitivity when compared with their wild type littermates.¹ These symptoms are highly associated with chronic diseases commonly seen in humans today, such as diabetes, obesity, and heart disease. PAS kinase is a highly conserved protein from yeast to man which allows for the use of yeast as model organism to help discover the molecular mechanisms behind PAS kinase function. Since little is known about how PAS kinase functions, it is important to identify interactions in human PAS kinase since metabolic pathways are not identical in humans and yeast. Thus, my research was intended to discover putative protein-protein interactions of human PAS kinase in order to determine the pathways that human PAS kinase regulates.

Recommended Citation

Hall, Tacie and Grose, Dr. Julianne (2023) "Identifying Proteins that Interact with Human PAS kinase," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1350.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1350