Assessing the Effects of the IRF5 Exon 1B on Translation

Authors

Jared Lambert, Brigham Young University
Dr. Brian Poole, Brigham Young University

Keywords

IRF5 risk allele, exon 1B, translation, Systemic Lupus Erythmatosus, SLE

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

With our lab’s previous finding revealing a hairpin folding structure in exon 1B (IRF5 risk allele), not found in the other first exons, this project was focused towards more fully understanding the role of IRF5 exon 1B’s hairpin structure and its effect on the translation of downstream proteins. The data acquired through this project will provide much needed information regarding the mechanism through which the risk allele of IRF5 affects the development of Systemic Lupus Erythmatosus (SLE).

Recommended Citation

Lambert, Jared and Poole, Dr. Brian (2023) "Assessing the Effects of the IRF5 Exon 1B on Translation," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1347.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1347