EBI2 Knockdown and Effects on B-Cell Migration

Authors

Jordan Mabey, Brigham Young University
Dr. Brian Poole, Brigham Young University

Keywords

EBI2, b-cell migration, immune response, Epstein-Barr virus induced molecule-2

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

B cells are specialized cells which participate in the normal immune response to an infection. As B cells encounter antigens in the body, they become activated and travel to what is known as a B cell follicle within a lymph node. At the outer follicle B cells combine with T cells and move to the inner follicle to become specialized immunity participating cells. Normally upon reaching the outer follicle, the B cell up-regulates Epstein-Barr virus induced molecule-2 (EBI2) which causes it to pause until the cell can complex with the proper T cell. Once this connection between the two cells has been established, EBI2 is down-regulated and the cell complex moves into the inner follicle (1).

Recommended Citation

Mabey, Jordan and Poole, Dr. Brian (2023) "EBI2 Knockdown and Effects on B-Cell Migration," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1346.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1346