Journal of Undergraduate Research
Keywords
vitamin D3, localized immunity, antibody secreting cells, lymphocytes
College
Life Sciences
Department
Microbiology and Molecular Biology
Abstract
The aim of our research was to help elucidate the degree of specificity employed by antibody secreting cells (lymphocytes) through a study of the role of CCR10 in the differential homing of these cells to mucosal issues. We used vitamin D3, known to upregulate expression of CCR10 on activated lymphocytes, as an adjuvant in our vaccines and tracked cell homing to mucosal tissues that express the CCR10 ligand CCL28 by detecting antigen specific antibody accumulation. Since mucosal tissues are ideal locations for vaccinations, the long-term aim was to develop a method for targeting antigen specific lymphocytes, and thus robust immune responses, to distinct mucosal tissues.
Recommended Citation
Vance, Kaitlyn and Wilson, Dr. Eric
(2023)
"Vitamin D3 as an Adjuvant to Produce Localized Immunity,"
Journal of Undergraduate Research: Vol. 2013:
Iss.
1, Article 1339.
Available at:
https://scholarsarchive.byu.edu/jur/vol2013/iss1/1339