A Nuclear Variant of Gdf5 may Present Novel Insights on Arthritis Formation

Authors

Michael Baldwin, Brigham Young University
Dr. Laura Bridgewater, Brigham Young University

Keywords

nuclear variant, Gdf5, arthritis formation, cartilage

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

More than 40 million Americans suffer from the pains of arthritis. Arthritis is characterized by joint inflammation and cartilage deterioration (3). For many years growth differentiation factor 5 (Gdf5) has been associated with cartilage formation and maintenance (4, 1). GDF5 has been traditionally regarded as a secreted growth factor; however, a new variant of Gdf5 was recently discovered in the nucleus. Nuclear Gdf5 (nGdf5) may present a new mechanism by which Gdf5 regulates cartilage development and preservation.

Recommended Citation

Baldwin, Michael and Bridgewater, Dr. Laura (2013) "A Nuclear Variant of Gdf5 may Present Novel Insights on Arthritis Formation," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1338.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1338