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Journal of Undergraduate Research

Keywords

PhoU, Escherichia coli, phosphate cell membranes

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Just as simpler systems are studied to better understand more complex systems, E. coli has long been a standard for biological experiments aimed at a more complete comprehension of the mechanisms that propitiate cell life. One of these vital mechanisms in E. coli is the uptake of phosphate (Pi) in varying levels of environmental phosphorous. Pi is a key element involved in cell membranes, DNA, RNA, and metabolism in E. coli. This uptake is accomplished by the cooperation of the PstSCAB2, PhoU, PhoR and PhoB proteins in phosphate poor environments1. PhoU acts as a negative regulator of the Pho operon which regulates the expression of the aforementioned proteins1. The mechanism through which PhoU completes this function is still unknown1.

Included in

Microbiology Commons

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