Determining Functions of a Nuclear Variant of the Growth Factor Bmp2

Authors

Evan D. Davis, Brigham Young University
Dr. Laura C. Bridgewater, Brigham Young University

Keywords

nuclear variant, growth factor, Bmp2, gRT-PCR

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Bone morphogenetic protein 2 (Bmp2) is a secreted growth factor that modulates many essential physiological and developmental processes by means of extracellular signaling (1). Several of these processes include neuronal differentiation, cardiac development, and skeletal muscle development (1-5). Dr. Laura Bridgewater at Brigham Young University recently identified a novel nuclear variant of Bmp2 that challenged its sole classification as a secreted growth factor (1). Subsequently, the Bridgewater lab demonstrated the existence of nuclear Bmp2 (nBmp2) and also characterized its origins.

Recommended Citation

Davis, Evan D. and Bridgewater, Dr. Laura C. (2013) "Determining Functions of a Nuclear Variant of the Growth Factor Bmp2," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1299.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1299