The Influence of the IRF 5 Risk Haplotype on EBV Gene Expression in B Cells

Authors

Brandon Henrie, Brigham Young University
Dr. Brian Poole, Brigham Young University

Keywords

IRF5, interferon regulatory factor 5, hapolotype, immune response, EBV gene

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

IRF5 (interferon regulatory factor 5) is an integral protein in the innate immune response to viruses in humans. Once activated, IRF5 acts as a transcription factor which facilitates the production of inflammatory cytokines, interferons, and a host of other anti-viral agents in humans. To date, there are twelve documented splice variants of IRF5 in the human population. These variants range from minor deletions to drastic changes in the protein makeup of IRF5. A risk IRF5 haplotype is a person possessing alleles coding for these radically altered IRF5 mRNA (Kozyrev). A protective IRF5 hapolotype is a person possessing alleles coding for complete IRF5 mRNA.

Recommended Citation

Henrie, Brandon and Poole, Dr. Brian (2013) "The Influence of the IRF 5 Risk Haplotype on EBV Gene Expression in B Cells," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1296.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1296