Inflammation and Apoptosis in Developing Dmm, cho, and sedc Articular Cartilage: The Role of the Unfolded Protein Response (UPR)

Authors

Caitlin Nichols, Brigham Young University
Dr. Laura Bridgewater, Brigham Young University

Keywords

inflammation, apoptosis, Dmm, cho, sedc, unfolded protein response, UPR

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

The purpose of this study was to determine whether the Dmm, cho, and sedc mutations in mice collagen genes activate unfolded protein response (UPR) pathways in developing cartilage tissues. The inflammation or cell death triggered by the UPR may contribute to the weakened articular cartilage and premature osteoarthritis (OA) observed in these mouse lines.

Recommended Citation

Nichols, Caitlin and Bridgewater, Dr. Laura (2013) "Inflammation and Apoptosis in Developing Dmm, cho, and sedc Articular Cartilage: The Role of the Unfolded Protein Response (UPR)," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1292.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1292