Mice show Decreased Muscle Strength bearing a Targeted Inactivation of nBmp2

Authors

Alina Schmidt, Brigham Young University
Dr. Laura Bridgewater, Brigham Young University

Keywords

mice, muscle strength, targeted inactivation, nBmp2, bone mophogenic protein 2

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

An important secreted growth factor, bone morphogenic protein 2 (Bmp2), is involved in mesoderm formation, heart development, neurogenesis, skeletal development, axis formation, and muscle development 1 and is a member of the TGF-β superfamily of proteins. Members of the TGF-β superfamily are commonly known as secreted growth factors but has recently been discovered in the nucleus, known as nuclear Bmp21. nBmp2 bypasses the secretory pathway by having an alternative start codon downstream of the signal peptide.

Recommended Citation

Schmidt, Alina and Bridgewater, Dr. Laura (2013) "Mice show Decreased Muscle Strength bearing a Targeted Inactivation of nBmp2," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1290.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1290