Binding Site Sequence Motifs Estrogen Receptor Mediation of Transcriptional Repression by Interactions Determined by Cis-Regulatory DNA Sequences

Authors

Brianna Teerlink, Brigham Young University
Dr. Chin-Yo Lin, Brigham Young University

Keywords

site sequence motifs, estrogen receptor, ER, transcriptional repression

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Breast cancer is the second-leading cause of cancer deaths in women in the United States and affects millions each year. Much of the current research on hormonal regulation in breast cancer systems focuses on up-regulation of genes (increased rates of transcription) by estrogen receptors (ERs); however, repression, or down-regulation, of genes can also play a significant role in estrogen-responsive expression of genes. (Lin et al., 2004) Since the mechanisms of down-regulation, or gene repression, have not been well-studied, information on repression becomes a foundation for potential future application of hormonal down-regulation to other cancer systems and biological processes.

Recommended Citation

Teerlink, Brianna and Lin, Dr. Chin-Yo (2013) "Binding Site Sequence Motifs Estrogen Receptor Mediation of Transcriptional Repression by Interactions Determined by Cis-Regulatory DNA Sequences," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1288.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1288