Gene Expression of Down-regulated Estrogen Receptor Target Genes in Human Breast Cancer Cells following Drug Rreatment

Authors

Ben Newman, Brigham Young University
Dr. Chin-Yo Lin, Brigham Young University

Keywords

gene expression, estrogen receptor target genes, human breast cancer, drug treatment

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Breast cancer is the most prevalent type of cancer found in women and the majority of such cancers are estrogen receptor (ER) positive. This means the cancer is dependent on estrogen for growth. In such cancers, ER acts as a ligand-dependent transcription factor, changing gene expression when bound to estrogen. The altered expression of ER target genes in breast cancer is a likely cause of the uncontrolled cell growth.

Recommended Citation

Newman, Ben and Lin, Dr. Chin-Yo (2013) "Gene Expression of Down-regulated Estrogen Receptor Target Genes in Human Breast Cancer Cells following Drug Rreatment," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1254.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1254