Nuclear Localization of GDF5 is Mediated by a Bipartite Nuclear Localization Signal

Authors

J. Daniel Jensen, Brigham Young University
Dr. Laura Bridgewater, Brigham Young University

Keywords

nuclear localization, GDF5, bipartite nuclear localization signal, biological function

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

GDF5, also known as cartilage-derived morphogenetic protein-1 (CDMP1), is a member of the transforming growth factor beta (TGFβ) protein superfamily. TGFβ proteins play an integral role in cell proliferation and differentiation, matrix synthesis, and apoptosis. First identified in 1981, highly-conserved TGFβ protein homologues have since been identified in a wide range of animal species, a compelling indication of their importance in biological function.

Recommended Citation

Jensen, J. Daniel and Bridgewater, Dr. Laura (2013) "Nuclear Localization of GDF5 is Mediated by a Bipartite Nuclear Localization Signal," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1245.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1245