The Role of RPL41 in Genetic Regulation of Col11a2

Authors

David William Timme, Brigham Young University

Keywords

RPL41, genetic regulation, Col11a2, ribosomal protein L41

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

The purpose of my research was to investigate what role ribosomal protein L41 (RPL41) has in regulating transcriptional activities of the Collagen 11a2 (Col11a2) gene. Prior to the ORCA grant, I had researched identifying possible transcription factors which bound to the B/C enhancer region of the Col11a2 gene, possibly regulating transcription. This work revealed that RPL41 could bind to the B/C enhancer in a eukaryotic (yeast) system. Since a protein binding to DNA could be relevant to transcriptional activity, unrelated to transcriptional regulation, or merely an artifact from the investigational method, it was important to examine the specific role RPL41 might play on regulation of the Col11a2 gene. This investigation was performed through use of transient transfections into rat chondrosarcoma (RCS) cells.

Recommended Citation

Timme, David William (2013) "The Role of RPL41 in Genetic Regulation of Col11a2," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1238.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1238