Journal of Undergraduate Research
Keywords
tumor-associated macrophage interaction, tumor microenvironment, chemotherapy
College
Life Sciences
Department
Microbiology and Molecular Biology
Abstract
Oncologists currently use chemotherapy and radiation to treat many cancers. The goal of both these treatments is to target cancerous cells without killing too many healthy ones. Both radiation and chemotherapy induce a form of cell death called apoptosis in an attempt to eliminate the body of a tumor. Current studies suggest that when tumor-associated macrophages ingest apoptotic cell debris, they fail to secrete pro-inflammatory mediators that would help clear the invader – whether a pathogen or a tumor – from the body. Ruptured necrotic cells, however, induce a strong inflammatory response that augments immune function. If macrophage engulfment of apoptotic cell debris truly does not trigger inflammation, macrophages are perhaps helping the tumor by aiding in tissue remodeling instead of killing it. If this is the case, current cancer treatments that cause massive cell death by apoptosis are influencing tumor-associated macrophages to tend toward a more tumor-friendly function, thus helping tumors develop and progress.
Recommended Citation
Aamodt, Heather and O'Neill, Dr. Kim L.
(2013)
"Tumor-associated Macrophage Interaction with the Tumor Microenvironment,"
Journal of Undergraduate Research: Vol. 2013:
Iss.
1, Article 1234.
Available at:
https://scholarsarchive.byu.edu/jur/vol2013/iss1/1234