Intracellular Localization of a Novel BMP-2 Variant Protein Involved in Col11a2 Regulation

Authors

Carolina M. Montaño, Brigham Young University
Dr. Laura C. Bridgewater, Brigham Young University

Keywords

intracellular localization, BMP-2 variant protein, Col11a2 regulation

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Cartilage is a type of connective tissue that is found in many parts of the skeleton and covers the joint surfaces of bones. It consists of an abundant extracellular matrix (ECM) that is produced and maintained by chondrocytes. This ECM includes type II, IX and XI collagens. Collagen XI plays a critical role in regulating fibril diameter and cartilage development. This heterotrimeric molecule consists of three chains—α1(XI), α2(XI), and α3(XI)—encoded by three distinct genes, Col11a1, Col11a2, and Col2a1, respectively.1 While expression of the α1(XI) and α3(XI) subunits is found in other tissues, the expression of the α2(XI) is restricted to chondrocytes.

Recommended Citation

Montaño, Carolina M. and Bridgewater, Dr. Laura C. (2013) "Intracellular Localization of a Novel BMP-2 Variant Protein Involved in Col11a2 Regulation," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1223.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1223