Journal of Undergraduate Research
Keywords
stromal-cell, macrophages, breast cancer cells, metastatic patterns
College
Life Sciences
Department
Microbiology and Molecular Biology
Abstract
Research has demonstrated that in some tumors, up to fifty percent of a breast tumor’s mass is composed of macrophages (1). It is well recognized that macrophages can inhibit tumor growth and, paradoxically, stimulate tumor growth and metastasis depending on the proteins produced (2). Macrophages located within the tumor environment are classified as tumor-associated macrophages. The migration of cancer cells from the primary tumor to a secondary site is a multipart process. How tumors are able to proliferate and invade into foreign areas is still unclear. However, it is becoming increasingly clear that the presence of macrophages in primary tumors is associated with an increased potential for tumors to migrate (2).
Recommended Citation
Twitchell, Devin and O'Neill, Dr. Kim L.
(2013)
"Stromal-cell Derived Factor-1α and Macrophages Increased Invasive Potential of Breast Cancer Cells,"
Journal of Undergraduate Research: Vol. 2013:
Iss.
1, Article 1218.
Available at:
https://scholarsarchive.byu.edu/jur/vol2013/iss1/1218