Loss of Scribble Tumor Suppressor in Human Cancers: Atypical hScrib Expression and Localization in Malignant Breast Cancer

Authors

Daniel F. Fuja, Brigham Young University
Dr. Kim L. O'Neill, Brigham Young University

Keywords

scribble tumor suppressor, human cancers, hScrib, milgnant breast cancer

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Drosophila Melanogaster has been used for years in basic developmental and genetic research, because of its short life cycle, low cost, and ease of handling. One beneficial consequence of this extensive research is an increased knowledge of human cancer progression. Multiple homologues have been found within the human model for genes initially discovered to be important in the development of Drosophila melanogaster. Three of these homologues (Hugl, hDlg, and hScrib) were initially indicated as potential tumor suppressors because of their Drosophila homologues’ roles in accurate asymmetric protein localization in the developing Drosophila neuroblast. Scribble (human homologue, hScrib), the most recently discovered gene of the set, is important in basolateral localization of integral proteins in Drosophila epithelium. In order to better understand the potential role of hScrib in regulation of cell polarity and the implications for cancer progression involved in the loss of that regulation, this study focused on the loss and alteration of hScrib in various breast cancer tumors.

Recommended Citation

Fuja, Daniel F. and O'Neill, Dr. Kim L. (2013) "Loss of Scribble Tumor Suppressor in Human Cancers: Atypical hScrib Expression and Localization in Malignant Breast Cancer," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1209.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1209