Analysis of HNF1-beta as a Possible Regulatory Protein for the Transcription of the Col11a2 Collagen Gene

Authors

Nicholas M. Orme, Brigham Young University
Dr. Laura C. Bridgewater, Brigham Young University

Keywords

HNF1-beta, regulatory protein, transcription, Col11a2 collagen gene

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

Cartilage is a highly specialized form of connective tissue that functions as a template for most skeletal structures and aids in supporting the tension and pressure common to most animal joint function. Abnormal cartilage formation often results from defective collagen DNA and can lead to several skeletal diseases including dwarfism, cleft palate and osteoarthritis. The purpose of this research was to investigate the regulatory role of HNF proteins in the transcription of the Col11a2 gene which codes for a collagen protein found in cartilage.

Recommended Citation

Orme, Nicholas M. and Bridgewater, Dr. Laura C. (2013) "Analysis of HNF1-beta as a Possible Regulatory Protein for the Transcription of the Col11a2 Collagen Gene," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1200.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1200