Identifying Selection in the ANGPTL4 Gene using TreeSAAP

Authors

Jeffrey Staples, Brigham Young University
Dr. Keith Crandall, Brigham Young University

Keywords

ANGPTL4 gene, TreeSAAP, diseases

College

Life Sciences

Department

Biology

Abstract

Geneticists have successfully identified the sources of many diseases that are inherited according to Mendelian rules (e.g. cystic fibrosis and Huntington’s disease). However, not all diseases are caused by one faulty gene; these so-called complex diseases (e.g. asthma, obesity, and diabetes) result from any number of mutated genes, faulty pathways, or environmental conditions. Association studies have identified a particular gene family (Angiopoietin-like proteins or ANGPTL) to be correlated with several of these complex diseases, namely diabetes, obesity, and heart disease1, 2; however, the function and contribution of these genes to these complex diseases is not completely understood.

Recommended Citation

Staples, Jeffrey and Crandall, Dr. Keith (2013) "Identifying Selection in the ANGPTL4 Gene using TreeSAAP," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1093.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1093