The CFTR Protein: Evolution and Disease

Authors

Adam Allred, Brigham Young University
Dr. David McClellan, Brigham Young University

Keywords

CFTR protein, evolution, disease, genetic disorder

College

Life Sciences

Department

Biology

Abstract

The principal aim of my research has been to aid in the understanding of complex molecular pathologies by identifying evolutionary patterns that maintain the structural and functional integrity of a particular protein product. A disease phenotype often results when such delicate patterns are disturbed. The Cystic Fibrosis Transmembrane conductance Regulator (CFTR), an epithelial chloride channel, has proven to be an especially worthy vehicle for understanding the link between molecular evolution and human disease. Aberrant functioning of this physiologically important channel results in cystic fibrosis, the most common lethal genetic disorder among European-derived populations.

Recommended Citation

Allred, Adam and McClellan, Dr. David (2013) "The CFTR Protein: Evolution and Disease," Journal of Undergraduate Research: Vol. 2013: Iss. 1, Article 1027.
Available at: https://scholarsarchive.byu.edu/jur/vol2013/iss1/1027