Keywords

nanoparticles, pH, drug delivery, cancer

Abstract

A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they enable the safe delivery of the drugs while controlling their release at the tumor sites. Different intrinsic and extrinsic stimuli can be used to trigger drug release such as temperature, redox, ultrasound, magnetic field, and pH. The intracellular pH of solid tumors is maintained below the extracellular pH. Thus, pH-sensitive nanoparticles are highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review provides a survey of the different strategies used to develop pH-sensitive nanoparticles used in cancer therapy.

Original Publication Citation

AlSawaftah, N.M., Awad, N.S., Pitt, W.G., Husseini, G.A.*, “pH-responsive Polymeric Micelles and Liposomes in Cancer Therapy”, Polymers, 14(5), 936 (2022). https://doi.org/10.3390/polym14050936 Epub 2022 Feb 26.

Document Type

Peer-Reviewed Article

Publication Date

2022-02-26

Publisher

MDPI

Language

English

College

Ira A. Fulton College of Engineering

Department

Chemical Engineering

University Standing at Time of Publication

Full Professor

Download

Share

COinS