Keywords
hyperthermia, thermosensitivity, liposomes, critical solution temperature, lysolipids, polymers
Abstract
Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites. This paper reviews the fundamentals of thermosensitive polymers, with a particular focus on thermoresponsive liposomal-based drug delivery systems.
Original Publication Citation
Abuwatfa, W.H., Awad, N.S., Pitt, W.G., Husseini, G.A.*, “Temperature-Sensitive Polymers and Nanocarrier-Based Systems”, Polymers, 14(5), 925 (2022). https://doi.org/10.3390/polym14050925 Epub 2022 Feb 25.
BYU ScholarsArchive Citation
Abuwatfa, Waad H.; Awad, Nahid S.; Pitt, William G.; and Husseini, Ghaleb A., "Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems" (2022). Faculty Publications. 7679.
https://scholarsarchive.byu.edu/facpub/7679
Document Type
Peer-Reviewed Article
Publication Date
2022-02-25
Publisher
MDPI
Language
English
College
Ira A. Fulton College of Engineering
Department
Chemical Engineering
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