Keywords
Hydration, vocal fold surface fluid, Sjogren's Syndrome, nebulized saline, CSID, throat dryness, vocal effort
Abstract
Objective: This study examined the effects of a topical vocal fold hydration treatment on voice production over time. Study Design: Prospective, longitudinal, within-subjects A (baseline), B (treatment), A (withdrawal/reversal), B (treatment) experimental design. Methods: Eight individuals with primary Sjogren’s syndrome (SS), an autoimmune disease causing laryngeal dryness, € completed an 8-week A-B-A-B experiment. Participants performed twice-daily audio recordings of connected speech and sustained vowels and then rated vocal effort, mouth dryness, and throat dryness. Two-week treatment phases introduced twicedaily 9-mL doses of nebulized isotonic saline (0.9% Na1Cl2). Voice handicap and patient-based measures of SS disease severity were collected before and after each 2-week phase. Connected speech and sustained vowels were analyzed using the Cepstral Spectral Index of Dysphonia (CSID). Acoustic and patient-based ratings during each baseline and treatment phase were analyzed and compared. Results: Baseline CSID and patient-based ratings were in the mild-to-moderate range. CSID measures of voice severity improved by approximately 20% with nebulized saline treatment and worsened during treatment withdrawal. Posttreatment CSID values fell within the normal-to-mild range. Similar patterns were observed in patient-based ratings of vocal effort and dryness. CSID values and patient-based ratings correlated significantly (P <.05). Conclusion: Nebulized isotonic saline improves voice production based on acoustic and patient-based ratings of voice severity. Future work should optimize topical vocal fold hydration treatment formulations, dose, and delivery methodologies for various patient populations. This study lays the groundwork for future topical vocal fold hydration treatment development to manage and possibly prevent dehydration-related voice disorders. Key Words: Hydration, vocal fold surface fluid, Sjogren’s Syndrome, nebulized saline, CSID, throat dryness, vocal effort.
Original Publication Citation
Tanner, K., Nissen, S. L., Merrill, R., Miner, A., Channell, R., Miller, K., Elstad, M., Kendall, K., & Roy, N. (2015). Nebulized isotonic saline improves voice production in Sjogren’s syndrome. Laryngoscope, 125(10), 2333-2340.
BYU ScholarsArchive Citation
Nissen, Shawn L.; Tanner, Kristine; Merrill, Ray M.; Miner, Alison; Channell, Ron W.; Miller, Karla L.; Elstad, Mark; Kendall, Katherine A.; and Roy, Nelson, "Nebulized isotonic saline improves voice production in Sjögren's syndrome" (2015). Faculty Publications. 7328.
https://scholarsarchive.byu.edu/facpub/7328
Document Type
Peer-Reviewed Article
Publication Date
2015
Publisher
The Laryngoscope
Language
English
College
David O. McKay School of Education
Department
Communication Disorders
Copyright Status
© 2015 The American Laryngological, Rhinological and Otological Society, Inc
Copyright Use Information
https://lib.byu.edu/about/copyright/