Keywords

semiflexible chain, DNA, high ionic strength buffer

Abstract

The classic results of de Gennes and Odijk describe the mobility of a semiflexible chain confined in a nanochannel only in the limits of very weak and very strong confinement, respectively. Using Monte Carlo sampling of the Kirkwood diffusivity with full hydrodynamic interactions, we show that the mobility of a semiflexible chain exhibits a broad plateau as a function of extension before transitioning to an Odijk regime, and that the width of the plateau depends on the anisotropy of the monomers. For the particular case of DNA in a high ionic strength buffer, which has highly anisotropic monomers, we predict that this Rouse-like behavior will be observed over most of the measurable chain extensions seen in experiments.

Original Publication Citation

Phys. Rev. Lett. 108, 228105

Document Type

Peer-Reviewed Article

Publication Date

2012-06-01

Publisher

American Physical Society

Language

English

College

Ira A. Fulton College of Engineering

Department

Chemical Engineering

University Standing at Time of Publication

Assistant Professor

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